Estradiol price at Cost Plus Drugs
The cash price for Estradiol at Mark Cuban Cost Plus Drug Company, PBC, without insurance, for each strength they sell. Then see how it compares with what 2027 Medicare plans near you would charge.
Estradiol at Cost Plus Drugs
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Estradiol Vaginal Estrogen Cream 0.01% Cream$13.21 per 1 Cream + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol (Twice Weekly) 0.0375mg Box of 8 Patches$94.61 per 1 Box of 8 Patches + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol (Twice Weekly) 0.075mg Box of 8 Patches$94.61 per 1 Box of 8 Patches + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol Oral Estrogen Tablet 0.5mg Tablet$6.04 for 30 · $8.11 for 90 + $5.25 shipping per orderAbout $53 a year, one a day, on 90-day ordersSee this at Cost Plus Drugs ↗
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Estradiol Oral Estrogen Tablet 1mg Tablet$6.77 for 30 · $10.30 for 90 + $5.25 shipping per orderAbout $62 a year, one a day, on 90-day ordersSee this at Cost Plus Drugs ↗
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Estradiol Oral Estrogen Tablet 2mg Tablet$6.84 for 30 · $10.51 for 90 + $5.25 shipping per orderAbout $63 a year, one a day, on 90-day ordersSee this at Cost Plus Drugs ↗
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Estradiol Vaginal Estrogen Tablet Insert 10mcg Vaginal Tablet$87.42 for 30 · $252.25 for 90 + $5.25 shipping per orderAbout $1030 a year, one a day, on 90-day ordersSee this at Cost Plus Drugs ↗
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Estradiol (Twice Weekly) 0.0375 mg/24hr Box of 8 Patches (Minivelle)$94.61 per 1 Box of 8 Patches + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol (Twice Weekly) 0.075 mg/24hr Box of 8 Patches (Minivelle)$94.61 per 1 Box of 8 Patches + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol (Twice Weekly) 0.1 mg/24hr Box of 8 Patches (Minivelle)$94.61 per 1 Box of 8 Patches + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol / Norethrindrone Acetate 0.5mg-0.1mg Blister Pack of 28 Tablets$17.32 per 1 Blister Pack of 28 Tablets + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
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Estradiol / Norethrindrone Acetate 1mg-0.5mg Blister Pack of 28 Tablets$13.18 per 1 Blister Pack of 28 Tablets + $5.25 shipping per orderSee this at Cost Plus Drugs ↗
Cost Plus Drugs' posted cash prices as of October 26, 2026, including their pharmacy fee. Prices can change; Cost Plus Drugs' website shows the current price. Yearly figures are estimates.
Medicare drug coverage for Estradiol in 2027
On 286 of 286 2027 Medicare drug lists (100%), most often on tier 4.
Some plans list it with quantity limits.
Each Medicare drug plan, and each Medicare Advantage plan with drug coverage, uses a drug list (formulary) that CMS publishes. Being on a plan's list means the plan covers the drug; what you pay depends on the plan's tier, deductible and pharmacy. Counts are from CMS's 2027 formulary files.
Compare with Medicare plans near you
Whether Cost Plus Drugs is lower than a Medicare plan depends on the plan, your other prescriptions and your pharmacy. Enter your ZIP code on the next page to see each 2027 plan's estimated yearly cost for Estradiol, next to the Cost Plus price.
Compare with 2027 Medicare plansAbout Estradiol at Cost Plus Drugs
- Drug group: Natural and semisynthetic estrogens, plain
- Brand-name version: Estrace, Vivelle-Dot, Vagifem, Activella. The prices above are for the generic unless a brand name is shown next to the strength.
- Forms sold at Cost Plus Drugs: cream, box of 8 patches, tablet, vaginal tablet, blister pack of 28 tablets
- Shipping: $5.25 per order, mailed to you. A prescription is required.
- Insurance: these are cash prices. Bought this way, outside your insurance, a drug generally doesn't count toward a Medicare plan's deductible or yearly out-of-pocket cap.